Gene information
Official symbol TIMP3
Official full name TIMP metallopeptidase inhibitor 3
Gene type protein-coding gene
Chromosome22q12.3
Previous symbolSFD
Gene familyTissue inhibitor of metallopeptidases
Resources
Entrez Gene 7078
HGNC HGNC:11822
Ensembl ENSG00000100234
Vega OTTHUMG00000030784
UCSC uc003anb.4
GO terms: 44 records
GO Description Category LogP Number of genes Detail
GO:0002020 protease binding GO Molecular Functions -28.8254555 31 More
GO:0004857 enzyme inhibitor activity GO Molecular Functions -18.4005452 35 More
GO:0004866 endopeptidase inhibitor activity GO Molecular Functions -20.0646267 27 More
GO:0005604 basement membrane GO Cellular Components -9.30297759 21 More
GO:0008191 metalloendopeptidase inhibitor activity GO Molecular Functions -5.83914312 5 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009895 negative regulation of catabolic process GO Biological Processes -10.3621088 43 More
GO:0010466 negative regulation of peptidase activity GO Biological Processes -24.1438543 35 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0010951 negative regulation of endopeptidase activity GO Biological Processes -24.7873219 35 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030414 peptidase inhibitor activity GO Molecular Functions -19.6181890 27 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031089 platelet dense granule lumen GO Cellular Components -6.16858707 5 More
GO:0031330 negative regulation of cellular catabolic process GO Biological Processes -6.88355184 32 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0034774 secretory granule lumen GO Cellular Components -58.3093741 66 More
GO:0042176 regulation of protein catabolic process GO Biological Processes -8.45353494 23 More
GO:0042177 negative regulation of protein catabolic process GO Biological Processes -5.18322511 10 More
GO:0042827 platelet dense granule GO Cellular Components -8.20976744 7 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043409 negative regulation of MAPK cascade GO Biological Processes -13.5471736 35 More
GO:0045861 negative regulation of proteolysis GO Biological Processes -27.9905009 43 More
GO:0051043 regulation of membrane protein ectodomain proteolysis GO Biological Processes -16.3022563 12 More
GO:0051045 negative regulation of membrane protein ectodomain proteolysis GO Biological Processes -7.69370672 5 More
GO:0051346 negative regulation of hydrolase activity GO Biological Processes -26.0030636 42 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0052548 regulation of endopeptidase activity GO Biological Processes -34.9486589 53 More
GO:0060205 cytoplasmic vesicle lumen GO Cellular Components -59.3932782 67 More
GO:0061134 peptidase regulator activity GO Molecular Functions -19.3582235 29 More
GO:0061135 endopeptidase regulator activity GO Molecular Functions -19.1908633 27 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO Biological Processes -3.72261873 5 More
GO:1902532 negative regulation of intracellular signal transduction GO Biological Processes -29.4927428 92 More
GO:1905049 negative regulation of metallopeptidase activity GO Biological Processes -7.64224943 8 More
GO:2001233 regulation of apoptotic signaling pathway GO Biological Processes -35.8481080 51 More
GO:2001235 positive regulation of apoptotic signaling pathway GO Biological Processes -13.4065813 30 More
GO:2001236 regulation of extrinsic apoptotic signaling pathway GO Biological Processes -20.7647111 26 More
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway GO Biological Processes -7.00132107 13 More
KEGG pathways: 1 record
KEGG Description Category LogP Number of genes Detail
hsa05205 Proteoglycans in cancer KEGG Pathway -18.5545131 27 More
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
metalloproteinase inhibitor 3 proteomics medium predictor left ventricular remodeling[prognosis (bad)] acute myocardial infarction Xie YT et al. Cardiovasc Diagn Ther. 2020
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